| Des Moines to Oxford (Alabama) | 694.59 mi (1,117.84 km) |
| Des Moines to Oxford (Mississippi) | 545.23 mi (877.46 km) |
| Des Moines to Oxford (Ohio) | 486.67 mi (783.22 km) |
| Des Moines to Oxnard (California) | 1,477.94 mi (2,378.52 km) |
| Des Moines to Oxon Hill (Maryland) | 897.58 mi (1,444.51 km) |
| Des Moines to Ozark (Alabama) | 826.55 mi (1,330.20 km) |
| Des Moines to Ozark (Missouri) | 314.12 mi (505.52 km) |
| Des Moines to Pace (Florida) | 837.34 mi (1,347.57 km) |
| Des Moines to Pacific Grove (California) | 1,549.00 mi (2,492.87 km) |
| Des Moines to Pacifica (California) | 1,553.68 mi (2,500.41 km) |
| Des Moines to Paducah (Kentucky) | 408.75 mi (657.82 km) |
| Des Moines to Pahrump (Nevada) | 1,255.11 mi (2,019.91 km) |
| Des Moines to Painesville (Ohio) | 637.51 mi (1,025.98 km) |
| Des Moines to Palatine (Illinois) | 288.98 mi (465.07 km) |
| Des Moines to Palatka (Florida) | 1,060.10 mi (1,706.07 km) |
