| Des Moines to Orangevale (California) | 1,465.78 mi (2,358.94 km) |
| Des Moines to Orchards (Washington) | 1,465.59 mi (2,358.64 km) |
| Des Moines to Orcutt (California) | 1,520.13 mi (2,446.42 km) |
| Des Moines to Oregon (Ohio) | 525.52 mi (845.74 km) |
| Des Moines to Oregon (Wisconsin) | 235.23 mi (378.56 km) |
| Des Moines to Oregon City (Oregon) | 1,468.45 mi (2,363.24 km) |
| Des Moines to Orem (Utah) | 946.53 mi (1,523.29 km) |
| Des Moines to Orinda (California) | 1,532.18 mi (2,465.81 km) |
| Des Moines to Orland Park (Illinois) | 297.02 mi (478.01 km) |
| Des Moines to Orlando (Florida) | 1,138.01 mi (1,831.46 km) |
| Des Moines to Ormond Beach (Florida) | 1,099.83 mi (1,770.01 km) |
| Des Moines to Oro Valley (Arizona) | 1,144.71 mi (1,842.23 km) |
| Des Moines to Oroville (California) | 1,468.34 mi (2,363.07 km) |
| Des Moines to Oshkosh (Wisconsin) | 306.78 mi (493.72 km) |
| Des Moines to Oskaloosa (Iowa) | 53.86 mi (86.67 km) |
