| Des Moines to Odessa (Texas) | 825.09 mi (1,327.85 km) |
| Des Moines to Ogden (Utah) | 949.94 mi (1,528.78 km) |
| Des Moines to Oildale (California) | 1,432.51 mi (2,305.41 km) |
| Des Moines to Ojus (Florida) | 1,323.44 mi (2,129.87 km) |
| Des Moines to Okemos (Michigan) | 477.41 mi (768.31 km) |
| Des Moines to Oklahoma City (Oklahoma) | 471.50 mi (758.80 km) |
| Des Moines to Okmulgee (Oklahoma) | 431.54 mi (694.50 km) |
| Des Moines to Olathe (Kansas) | 196.45 mi (316.15 km) |
| Des Moines to Old Jamestown (Missouri) | 257.75 mi (414.82 km) |
| Des Moines to Oldsmar (Florida) | 1,119.50 mi (1,801.66 km) |
| Des Moines to Olean (New York) | 781.23 mi (1,257.27 km) |
| Des Moines to Olive Branch (Mississippi) | 500.22 mi (805.03 km) |
| Des Moines to Olivehurst (California) | 1,475.59 mi (2,374.73 km) |
| Des Moines to Olney (Maryland) | 885.29 mi (1,424.74 km) |
| Des Moines to Olympia (Washington) | 1,486.88 mi (2,392.91 km) |
