| Des Moines to Oakley (California) | 1,504.72 mi (2,421.62 km) |
| Des Moines to Oakton (Virginia) | 878.61 mi (1,413.99 km) |
| Des Moines to Oakville (Missouri) | 277.32 mi (446.30 km) |
| Des Moines to Oatfield (Oregon) | 1,468.52 mi (2,363.36 km) |
| Des Moines to Ocala (Florida) | 1,070.33 mi (1,722.53 km) |
| Des Moines to Ocean Acres (New Jersey) | 1,018.87 mi (1,639.71 km) |
| Des Moines to Ocean City (New Jersey) | 1,010.34 mi (1,625.99 km) |
| Des Moines to Ocean Pines (Maryland) | 999.87 mi (1,609.13 km) |
| Des Moines to Ocean Pointe (Hawaii) | 3,950.12 mi (6,357.11 km) |
| Des Moines to Ocean Springs (Mississippi) | 816.80 mi (1,314.51 km) |
| Des Moines to Oceanside (California) | 1,416.84 mi (2,280.18 km) |
| Des Moines to Oceanside (New York) | 1,039.63 mi (1,673.13 km) |
| Des Moines to Ocoee (Florida) | 1,125.49 mi (1,811.31 km) |
| Des Moines to Oconomowoc (Wisconsin) | 281.72 mi (453.38 km) |
| Des Moines to Odenton (Maryland) | 906.29 mi (1,458.53 km) |
