| Des Moines to Mineral Wells (Texas) | 652.75 mi (1,050.50 km) |
| Des Moines to Minneapolis (Minnesota) | 234.93 mi (378.08 km) |
| Des Moines to Minnehaha (Washington) | 1,469.90 mi (2,365.58 km) |
| Des Moines to Minneola (Florida) | 1,117.23 mi (1,798.01 km) |
| Des Moines to Minnetonka (Minnesota) | 232.26 mi (373.78 km) |
| Des Moines to Minooka (Illinois) | 275.92 mi (444.06 km) |
| Des Moines to Minot (North Dakota) | 593.40 mi (954.99 km) |
| Des Moines to Mint Hill (North Carolina) | 827.96 mi (1,332.48 km) |
| Des Moines to Miramar (Florida) | 1,316.48 mi (2,118.67 km) |
| Des Moines to Mishawaka (Indiana) | 384.42 mi (618.66 km) |
| Des Moines to Mission (Texas) | 1,095.29 mi (1,762.69 km) |
| Des Moines to Mission Bend (Texas) | 828.67 mi (1,333.62 km) |
| Des Moines to Mission Viejo (California) | 1,420.67 mi (2,286.35 km) |
| Des Moines to Missoula (Montana) | 1,071.22 mi (1,723.96 km) |
| Des Moines to Missouri City (Texas) | 836.74 mi (1,346.61 km) |
