| Des Moines to Merrick (New York) | 1,043.69 mi (1,679.65 km) |
| Des Moines to Merrifield (Virginia) | 881.96 mi (1,419.38 km) |
| Des Moines to Merrillville (Indiana) | 325.43 mi (523.72 km) |
| Des Moines to Merritt Island (Florida) | 1,170.31 mi (1,883.43 km) |
| Des Moines to Mesa (Arizona) | 1,138.67 mi (1,832.51 km) |
| Des Moines to Mesquite (Nevada) | 1,144.20 mi (1,841.41 km) |
| Des Moines to Mesquite (Texas) | 630.42 mi (1,014.56 km) |
| Des Moines to Metairie (Louisiana) | 822.36 mi (1,323.46 km) |
| Des Moines to Methuen Town (Massachusetts) | 1,147.90 mi (1,847.37 km) |
| Des Moines to Metuchen (New Jersey) | 1,003.24 mi (1,614.56 km) |
| Des Moines to Mexico (Missouri) | 190.02 mi (305.80 km) |
| Des Moines to Miami (Florida) | 1,331.93 mi (2,143.53 km) |
| Des Moines to Miami (Oklahoma) | 330.63 mi (532.09 km) |
| Des Moines to Miami Beach (Florida) | 1,332.29 mi (2,144.11 km) |
| Des Moines to Miami Gardens (Florida) | 1,321.50 mi (2,126.75 km) |
