| Des Moines to Medford (New York) | 1,070.96 mi (1,723.54 km) |
| Des Moines to Medford (Oregon) | 1,496.12 mi (2,407.77 km) |
| Des Moines to Medina (Ohio) | 609.21 mi (980.44 km) |
| Des Moines to Medulla (Florida) | 1,146.64 mi (1,845.34 km) |
| Des Moines to Mehlville (Missouri) | 274.56 mi (441.85 km) |
| Des Moines to Melbourne (Florida) | 1,182.22 mi (1,902.60 km) |
| Des Moines to Melissa (Texas) | 594.62 mi (956.95 km) |
| Des Moines to Melrose (Massachusetts) | 1,155.88 mi (1,860.21 km) |
| Des Moines to Melrose Park (Illinois) | 297.12 mi (478.16 km) |
| Des Moines to Melville (New York) | 1,049.60 mi (1,689.17 km) |
| Des Moines to Melvindale (Michigan) | 538.16 mi (866.09 km) |
| Des Moines to Memphis (Florida) | 1,153.12 mi (1,855.77 km) |
| Des Moines to Memphis (Tennessee) | 488.19 mi (785.67 km) |
| Des Moines to Menasha (Wisconsin) | 319.46 mi (514.11 km) |
| Des Moines to Mendota (California) | 1,465.69 mi (2,358.80 km) |
