| Des Moines to McKeesport (Pennsylvania) | 722.56 mi (1,162.84 km) |
| Des Moines to McKinleyville (California) | 1,575.17 mi (2,534.99 km) |
| Des Moines to McKinney (Texas) | 602.11 mi (968.99 km) |
| Des Moines to McLean (Virginia) | 883.00 mi (1,421.04 km) |
| Des Moines to McMinnville (Oregon) | 1,497.67 mi (2,410.27 km) |
| Des Moines to McMinnville (Tennessee) | 586.02 mi (943.10 km) |
| Des Moines to McNair (Virginia) | 871.69 mi (1,402.84 km) |
| Des Moines to McPherson (Kansas) | 308.00 mi (495.67 km) |
| Des Moines to Mead Valley (California) | 1,394.55 mi (2,244.32 km) |
| Des Moines to Meadow Woods (Florida) | 1,143.84 mi (1,840.84 km) |
| Des Moines to Meadowbrook (Virginia) | 905.01 mi (1,456.47 km) |
| Des Moines to Meadville (Pennsylvania) | 694.84 mi (1,118.24 km) |
| Des Moines to Mebane (North Carolina) | 858.30 mi (1,381.30 km) |
| Des Moines to Mechanicsville (Virginia) | 905.66 mi (1,457.52 km) |
| Des Moines to Medford (Massachusetts) | 1,153.53 mi (1,856.43 km) |
