| Des Moines to Mauldin (South Carolina) | 771.73 mi (1,241.98 km) |
| Des Moines to Maumee (Ohio) | 513.88 mi (827.01 km) |
| Des Moines to Maumelle (Arkansas) | 468.94 mi (754.69 km) |
| Des Moines to Mayagüez (Puerto Rico) | 2,245.18 mi (3,613.26 km) |
| Des Moines to Mayfield Heights (Ohio) | 628.16 mi (1,010.92 km) |
| Des Moines to Mays Chapel (Maryland) | 901.60 mi (1,450.99 km) |
| Des Moines to Maywood (California) | 1,434.59 mi (2,308.75 km) |
| Des Moines to Maywood (Illinois) | 298.05 mi (479.66 km) |
| Des Moines to McAlester (Oklahoma) | 473.96 mi (762.77 km) |
| Des Moines to McAllen (Texas) | 1,092.76 mi (1,758.62 km) |
| Des Moines to McCalla (Alabama) | 675.40 mi (1,086.95 km) |
| Des Moines to McComb (Mississippi) | 734.50 mi (1,182.07 km) |
| Des Moines to McDonough (Georgia) | 763.63 mi (1,228.95 km) |
| Des Moines to McFarland (California) | 1,436.14 mi (2,311.25 km) |
| Des Moines to McHenry (Illinois) | 278.25 mi (447.79 km) |
