| Des Moines to Lowell (Indiana) | 321.22 mi (516.96 km) |
| Des Moines to Lowell (Massachusetts) | 1,141.61 mi (1,837.24 km) |
| Des Moines to Lower Burrell (Pennsylvania) | 726.22 mi (1,168.74 km) |
| Des Moines to Lowes Island (Virginia) | 872.79 mi (1,404.62 km) |
| Des Moines to Lubbock (Texas) | 714.48 mi (1,149.84 km) |
| Des Moines to Lufkin (Texas) | 710.96 mi (1,144.18 km) |
| Des Moines to Luling (Louisiana) | 826.70 mi (1,330.44 km) |
| Des Moines to Lumberton (North Carolina) | 925.18 mi (1,488.93 km) |
| Des Moines to Lumberton (Texas) | 782.59 mi (1,259.45 km) |
| Des Moines to Lutz (Florida) | 1,121.21 mi (1,804.41 km) |
| Des Moines to Lynbrook (New York) | 1,037.38 mi (1,669.50 km) |
| Des Moines to Lynchburg (Virginia) | 819.92 mi (1,319.54 km) |
| Des Moines to Lynden (Washington) | 1,481.71 mi (2,384.58 km) |
| Des Moines to Lyndhurst (Ohio) | 626.16 mi (1,007.70 km) |
| Des Moines to Lyndon (Kentucky) | 482.33 mi (776.24 km) |
