| Des Moines to Los Alamos (New Mexico) | 786.70 mi (1,266.07 km) |
| Des Moines to Los Altos (California) | 1,539.55 mi (2,477.67 km) |
| Des Moines to Los Angeles (California) | 1,441.49 mi (2,319.85 km) |
| Des Moines to Los Banos (California) | 1,481.97 mi (2,384.99 km) |
| Des Moines to Los Gatos (California) | 1,535.55 mi (2,471.24 km) |
| Des Moines to Los Lunas (New Mexico) | 852.71 mi (1,372.31 km) |
| Des Moines to Los Osos (California) | 1,527.83 mi (2,458.81 km) |
| Des Moines to Loudoun Valley Estates (Virginia) | 866.35 mi (1,394.25 km) |
| Des Moines to Louisville (Colorado) | 613.07 mi (986.64 km) |
| Des Moines to Louisville (Kentucky) | 483.09 mi (777.46 km) |
| Des Moines to Lovejoy (Georgia) | 757.32 mi (1,218.79 km) |
| Des Moines to Loveland (Colorado) | 602.07 mi (968.93 km) |
| Des Moines to Loveland (Ohio) | 516.00 mi (830.43 km) |
| Des Moines to Loves Park (Illinois) | 242.80 mi (390.75 km) |
| Des Moines to Lovington (New Mexico) | 801.20 mi (1,289.41 km) |
