| Des Moines to Lewiston (Maine) | 1,196.34 mi (1,925.33 km) |
| Des Moines to Lewisville (North Carolina) | 803.13 mi (1,292.51 km) |
| Des Moines to Lewisville (Texas) | 617.46 mi (993.71 km) |
| Des Moines to Lexington (Kentucky) | 543.15 mi (874.12 km) |
| Des Moines to Lexington (Nebraska) | 323.71 mi (520.96 km) |
| Des Moines to Lexington (North Carolina) | 821.32 mi (1,321.79 km) |
| Des Moines to Lexington (South Carolina) | 854.29 mi (1,374.84 km) |
| Des Moines to Lexington Park (Maryland) | 936.56 mi (1,507.25 km) |
| Des Moines to Liberal (Kansas) | 500.56 mi (805.57 km) |
| Des Moines to Liberty (Missouri) | 166.72 mi (268.31 km) |
| Des Moines to Liberty Lake (Washington) | 1,223.95 mi (1,969.76 km) |
| Des Moines to Liberty Triangle (Florida) | 1,073.92 mi (1,728.31 km) |
| Des Moines to Libertyville (Illinois) | 294.21 mi (473.48 km) |
| Des Moines to Lighthouse Point (Florida) | 1,307.00 mi (2,103.41 km) |
| Des Moines to Lilburn (Georgia) | 740.58 mi (1,191.85 km) |
