| Des Moines to Largo (Florida) | 1,124.83 mi (1,810.24 km) |
| Des Moines to Largo (Maryland) | 903.06 mi (1,453.34 km) |
| Des Moines to Larkspur (California) | 1,549.11 mi (2,493.04 km) |
| Des Moines to Las Cruces (New Mexico) | 966.28 mi (1,555.08 km) |
| Des Moines to Las Vegas (Nevada) | 1,217.59 mi (1,959.52 km) |
| Des Moines to Las Vegas (New Mexico) | 749.56 mi (1,206.30 km) |
| Des Moines to Latham (New York) | 1,018.10 mi (1,638.47 km) |
| Des Moines to Lathrop (California) | 1,489.02 mi (2,396.34 km) |
| Des Moines to Lauderdale Lakes (Florida) | 1,309.68 mi (2,107.73 km) |
| Des Moines to Lauderhill (Florida) | 1,309.39 mi (2,107.26 km) |
| Des Moines to Laurel (Florida) | 1,179.96 mi (1,898.96 km) |
| Des Moines to Laurel (Maryland) | 897.06 mi (1,443.68 km) |
| Des Moines to Laurel (Mississippi) | 725.67 mi (1,167.85 km) |
| Des Moines to Laurel (Virginia) | 897.78 mi (1,444.83 km) |
| Des Moines to Laurinburg (North Carolina) | 898.81 mi (1,446.49 km) |
