| Des Moines to Iselin (New Jersey) | 1,005.26 mi (1,617.81 km) |
| Des Moines to Isla Vista (California) | 1,505.55 mi (2,422.96 km) |
| Des Moines to Issaquah (Washington) | 1,450.27 mi (2,333.98 km) |
| Des Moines to Ithaca (New York) | 878.85 mi (1,414.37 km) |
| Des Moines to Ives Estates (Florida) | 1,322.30 mi (2,128.03 km) |
| Des Moines to Jackson (Michigan) | 475.44 mi (765.15 km) |
| Des Moines to Jackson (Mississippi) | 666.38 mi (1,072.44 km) |
| Des Moines to Jackson (Missouri) | 358.39 mi (576.77 km) |
| Des Moines to Jackson (Tennessee) | 483.22 mi (777.68 km) |
| Des Moines to Jackson (Wyoming) | 882.22 mi (1,419.80 km) |
| Des Moines to Jacksonville (Alabama) | 686.54 mi (1,104.89 km) |
| Des Moines to Jacksonville (Arkansas) | 469.26 mi (755.21 km) |
| Des Moines to Jacksonville (Florida) | 1,022.04 mi (1,644.81 km) |
| Des Moines to Jacksonville (Illinois) | 218.13 mi (351.04 km) |
| Des Moines to Jacksonville (North Carolina) | 997.65 mi (1,605.57 km) |
