| Des Moines to Indianola (Iowa) | 14.67 mi (23.61 km) |
| Des Moines to Indio (California) | 1,345.64 mi (2,165.61 km) |
| Des Moines to Inglewood (California) | 1,443.53 mi (2,323.13 km) |
| Des Moines to Inkster (Michigan) | 531.21 mi (854.91 km) |
| Des Moines to Inver Grove Heights (Minnesota) | 226.41 mi (364.37 km) |
| Des Moines to Inwood (New York) | 1,033.87 mi (1,663.86 km) |
| Des Moines to Iona (Florida) | 1,233.10 mi (1,984.49 km) |
| Des Moines to Ionia (Michigan) | 446.93 mi (719.27 km) |
| Des Moines to Iowa City (Iowa) | 107.61 mi (173.18 km) |
| Des Moines to Irmo (South Carolina) | 850.21 mi (1,368.28 km) |
| Des Moines to Irondale (Alabama) | 672.23 mi (1,081.86 km) |
| Des Moines to Ironton (Ohio) | 614.64 mi (989.16 km) |
| Des Moines to Irvine (California) | 1,424.29 mi (2,292.18 km) |
| Des Moines to Irving (Texas) | 629.69 mi (1,013.38 km) |
| Des Moines to Isabela (Puerto Rico) | 2,233.85 mi (3,595.03 km) |
