| Des Moines to Hutchinson (Minnesota) | 232.13 mi (373.58 km) |
| Des Moines to Hutto (Texas) | 793.08 mi (1,276.35 km) |
| Des Moines to Hyattsville (Maryland) | 894.94 mi (1,440.27 km) |
| Des Moines to Hybla Valley (Virginia) | 892.81 mi (1,436.83 km) |
| Des Moines to Idaho Falls (Idaho) | 945.46 mi (1,521.58 km) |
| Des Moines to Idylwood (Virginia) | 883.52 mi (1,421.89 km) |
| Des Moines to Ilchester (Maryland) | 899.53 mi (1,447.65 km) |
| Des Moines to Immokalee (Florida) | 1,255.07 mi (2,019.84 km) |
| Des Moines to Imperial (California) | 1,345.51 mi (2,165.40 km) |
| Des Moines to Imperial Beach (California) | 1,431.22 mi (2,303.33 km) |
| Des Moines to Independence (Kentucky) | 510.62 mi (821.77 km) |
| Des Moines to Independence (Missouri) | 176.09 mi (283.38 km) |
| Des Moines to Indian Trail (North Carolina) | 832.74 mi (1,340.17 km) |
| Des Moines to Indiana (Pennsylvania) | 754.63 mi (1,214.46 km) |
| Des Moines to Indianapolis (Indiana) | 410.20 mi (660.16 km) |
