| Des Moines to Friendswood (Texas) | 838.09 mi (1,348.78 km) |
| Des Moines to Frisco (Texas) | 607.54 mi (977.75 km) |
| Des Moines to Front Royal (Virginia) | 832.59 mi (1,339.93 km) |
| Des Moines to Fruit Cove (Florida) | 1,037.05 mi (1,668.98 km) |
| Des Moines to Fruita (Colorado) | 812.21 mi (1,307.12 km) |
| Des Moines to Fruitville (Florida) | 1,168.77 mi (1,880.96 km) |
| Des Moines to Fuller Heights (Florida) | 1,148.29 mi (1,848.00 km) |
| Des Moines to Fullerton (California) | 1,425.02 mi (2,293.35 km) |
| Des Moines to Fullerton (Pennsylvania) | 944.28 mi (1,519.68 km) |
| Des Moines to Fulshear (Texas) | 830.54 mi (1,336.63 km) |
| Des Moines to Fulton (Missouri) | 207.16 mi (333.38 km) |
| Des Moines to Fulton (New York) | 883.28 mi (1,421.50 km) |
| Des Moines to Fuquay-Varina (North Carolina) | 899.58 mi (1,447.73 km) |
| Des Moines to Gadsden (Alabama) | 666.56 mi (1,072.72 km) |
| Des Moines to Gaffney (South Carolina) | 787.18 mi (1,266.85 km) |
