| Des Moines to Frederick (Maryland) | 862.30 mi (1,387.74 km) |
| Des Moines to Fredericksburg (Texas) | 834.45 mi (1,342.92 km) |
| Des Moines to Fredericksburg (Virginia) | 882.14 mi (1,419.67 km) |
| Des Moines to Frederickson (Washington) | 1,462.00 mi (2,352.86 km) |
| Des Moines to Freeport (Illinois) | 210.26 mi (338.38 km) |
| Des Moines to Freeport (New York) | 1,042.06 mi (1,677.03 km) |
| Des Moines to Freeport (Texas) | 877.96 mi (1,412.95 km) |
| Des Moines to Fremont (California) | 1,530.09 mi (2,462.44 km) |
| Des Moines to Fremont (Nebraska) | 149.13 mi (240.00 km) |
| Des Moines to Fremont (Ohio) | 543.32 mi (874.39 km) |
| Des Moines to French Valley (California) | 1,393.67 mi (2,242.90 km) |
| Des Moines to Fresno (California) | 1,434.92 mi (2,309.28 km) |
| Des Moines to Fresno (Texas) | 838.14 mi (1,348.86 km) |
| Des Moines to Fridley (Minnesota) | 243.27 mi (391.50 km) |
| Des Moines to Friendly (Maryland) | 898.61 mi (1,446.17 km) |
