| Des Moines to Euless (Texas) | 631.97 mi (1,017.06 km) |
| Des Moines to Eureka (California) | 1,580.99 mi (2,544.35 km) |
| Des Moines to Eureka (Missouri) | 263.77 mi (424.50 km) |
| Des Moines to Eustis (Florida) | 1,104.77 mi (1,777.96 km) |
| Des Moines to Evans (Colorado) | 586.10 mi (943.24 km) |
| Des Moines to Evans (Georgia) | 836.08 mi (1,345.54 km) |
| Des Moines to Evanston (Illinois) | 306.37 mi (493.06 km) |
| Des Moines to Evanston (Wyoming) | 897.94 mi (1,445.10 km) |
| Des Moines to Evansville (Indiana) | 406.56 mi (654.30 km) |
| Des Moines to Everett (Massachusetts) | 1,156.39 mi (1,861.03 km) |
| Des Moines to Everett (Washington) | 1,458.98 mi (2,348.00 km) |
| Des Moines to Evergreen Park (Illinois) | 305.21 mi (491.18 km) |
| Des Moines to Ewa Beach (Hawaii) | 3,948.86 mi (6,355.07 km) |
| Des Moines to Ewa Gentry (Hawaii) | 3,949.16 mi (6,355.56 km) |
| Des Moines to Excelsior Springs (Missouri) | 157.83 mi (254.00 km) |
