| Des Moines to Enumclaw (Washington) | 1,445.29 mi (2,325.98 km) |
| Des Moines to Ephrata (Pennsylvania) | 914.04 mi (1,471.01 km) |
| Des Moines to Erie (Colorado) | 606.56 mi (976.17 km) |
| Des Moines to Erie (Pennsylvania) | 697.06 mi (1,121.81 km) |
| Des Moines to Erlanger (Kentucky) | 507.14 mi (816.17 km) |
| Des Moines to Escanaba (Michigan) | 434.99 mi (700.06 km) |
| Des Moines to Escondido (California) | 1,408.35 mi (2,266.52 km) |
| Des Moines to Española (New Mexico) | 772.29 mi (1,242.88 km) |
| Des Moines to Essex (Maryland) | 914.64 mi (1,471.98 km) |
| Des Moines to Essex Junction (Vermont) | 1,051.70 mi (1,692.55 km) |
| Des Moines to Estelle (Louisiana) | 833.67 mi (1,341.66 km) |
| Des Moines to Estero (Florida) | 1,243.46 mi (2,001.15 km) |
| Des Moines to Euclid (Ohio) | 624.42 mi (1,004.91 km) |
| Des Moines to Eufaula (Alabama) | 814.59 mi (1,310.96 km) |
| Des Moines to Eugene (Oregon) | 1,497.24 mi (2,409.58 km) |
