| Des Moines to Emeryville (California) | 1,539.03 mi (2,476.83 km) |
| Des Moines to Emmaus (Pennsylvania) | 944.70 mi (1,520.34 km) |
| Des Moines to Emporia (Kansas) | 258.15 mi (415.45 km) |
| Des Moines to Encinitas (California) | 1,420.76 mi (2,286.48 km) |
| Des Moines to Endicott (New York) | 902.42 mi (1,452.31 km) |
| Des Moines to Endwell (New York) | 904.49 mi (1,455.63 km) |
| Des Moines to Englewood (Colorado) | 611.26 mi (983.73 km) |
| Des Moines to Englewood (Florida) | 1,193.78 mi (1,921.20 km) |
| Des Moines to Englewood (New Jersey) | 1,019.24 mi (1,640.31 km) |
| Des Moines to Englewood (Ohio) | 501.02 mi (806.31 km) |
| Des Moines to Enid (Oklahoma) | 423.82 mi (682.08 km) |
| Des Moines to Ennis (Texas) | 660.25 mi (1,062.57 km) |
| Des Moines to Ensley (Florida) | 840.72 mi (1,353.02 km) |
| Des Moines to Enterprise (Alabama) | 828.16 mi (1,332.80 km) |
| Des Moines to Enterprise (Nevada) | 1,222.12 mi (1,966.82 km) |
