| Des Moines to Elkhorn (Wisconsin) | 270.78 mi (435.78 km) |
| Des Moines to Elko (Nevada) | 1,149.75 mi (1,850.34 km) |
| Des Moines to Elkridge (Maryland) | 901.30 mi (1,450.51 km) |
| Des Moines to Elkton (Maryland) | 941.51 mi (1,515.21 km) |
| Des Moines to Ellensburg (Washington) | 1,376.43 mi (2,215.15 km) |
| Des Moines to Ellicott City (Maryland) | 895.02 mi (1,440.40 km) |
| Des Moines to Elmhurst (Illinois) | 293.01 mi (471.56 km) |
| Des Moines to Elmira (New York) | 864.27 mi (1,390.91 km) |
| Des Moines to Elmont (New York) | 1,035.10 mi (1,665.84 km) |
| Des Moines to Elmwood Park (Illinois) | 299.61 mi (482.17 km) |
| Des Moines to Elmwood Park (New Jersey) | 1,011.54 mi (1,627.92 km) |
| Des Moines to Elon (North Carolina) | 846.44 mi (1,362.21 km) |
| Des Moines to Eloy (Arizona) | 1,159.63 mi (1,866.24 km) |
| Des Moines to Elwood (New York) | 1,052.48 mi (1,693.80 km) |
| Des Moines to Elyria (Ohio) | 595.28 mi (958.02 km) |
