| Des Moines to El Sobrante (California) | 1,402.09 mi (2,256.45 km) |
| Des Moines to Eldersburg (Maryland) | 886.61 mi (1,426.86 km) |
| Des Moines to Elfers (Florida) | 1,108.14 mi (1,783.38 km) |
| Des Moines to Elgin (Illinois) | 274.12 mi (441.16 km) |
| Des Moines to Elizabeth (New Jersey) | 1,010.59 mi (1,626.39 km) |
| Des Moines to Elizabeth City (North Carolina) | 1,000.27 mi (1,609.77 km) |
| Des Moines to Elizabethton (Tennessee) | 709.26 mi (1,141.45 km) |
| Des Moines to Elizabethtown (Kentucky) | 490.39 mi (789.21 km) |
| Des Moines to Elizabethtown (Pennsylvania) | 892.84 mi (1,436.88 km) |
| Des Moines to Elk City (Oklahoma) | 530.54 mi (853.82 km) |
| Des Moines to Elk Grove (California) | 1,479.70 mi (2,381.35 km) |
| Des Moines to Elk Grove Village (Illinois) | 290.93 mi (468.21 km) |
| Des Moines to Elk Plain (Washington) | 1,462.02 mi (2,352.89 km) |
| Des Moines to Elk River (Minnesota) | 259.72 mi (417.99 km) |
| Des Moines to Elkhart (Indiana) | 394.90 mi (635.54 km) |
