| Des Moines to Eau Claire (Wisconsin) | 248.36 mi (399.70 km) |
| Des Moines to Echelon (New Jersey) | 980.24 mi (1,577.55 km) |
| Des Moines to Eden (North Carolina) | 821.32 mi (1,321.79 km) |
| Des Moines to Eden Prairie (Minnesota) | 226.50 mi (364.51 km) |
| Des Moines to Edgewater (Florida) | 1,124.49 mi (1,809.69 km) |
| Des Moines to Edgewater (New Jersey) | 1,019.98 mi (1,641.49 km) |
| Des Moines to Edgewood (Maryland) | 920.19 mi (1,480.91 km) |
| Des Moines to Edgewood (Washington) | 1,459.19 mi (2,348.34 km) |
| Des Moines to Edina (Minnesota) | 229.66 mi (369.60 km) |
| Des Moines to Edinburg (Texas) | 1,085.21 mi (1,746.47 km) |
| Des Moines to Edmond (Oklahoma) | 456.58 mi (734.80 km) |
| Des Moines to Edmonds (Washington) | 1,466.42 mi (2,359.98 km) |
| Des Moines to Edwards (Colorado) | 694.90 mi (1,118.34 km) |
| Des Moines to Edwardsville (Illinois) | 271.02 mi (436.17 km) |
| Des Moines to Effingham (Illinois) | 315.65 mi (507.99 km) |
