| Des Moines to Dumas (Texas) | 598.24 mi (962.78 km) |
| Des Moines to Dumont (New Jersey) | 1,017.70 mi (1,637.83 km) |
| Des Moines to Duncan (Oklahoma) | 539.30 mi (867.92 km) |
| Des Moines to Duncanville (Texas) | 642.90 mi (1,034.64 km) |
| Des Moines to Dundalk (Maryland) | 912.68 mi (1,468.82 km) |
| Des Moines to Dunedin (Florida) | 1,116.96 mi (1,797.57 km) |
| Des Moines to Dunkirk (New York) | 734.63 mi (1,182.27 km) |
| Des Moines to Dunmore (Pennsylvania) | 930.09 mi (1,496.84 km) |
| Des Moines to Dunwoody (Georgia) | 731.22 mi (1,176.79 km) |
| Des Moines to Durango (Colorado) | 816.37 mi (1,313.82 km) |
| Des Moines to Durant (Oklahoma) | 545.06 mi (877.20 km) |
| Des Moines to Durham (North Carolina) | 879.90 mi (1,416.06 km) |
| Des Moines to Dyer (Indiana) | 315.54 mi (507.82 km) |
| Des Moines to Dyersburg (Tennessee) | 444.51 mi (715.36 km) |
| Des Moines to Eagan (Minnesota) | 225.30 mi (362.58 km) |
