| Des Moines to Desert Hot Springs (California) | 1,353.37 mi (2,178.03 km) |
| Des Moines to DeSoto (Texas) | 645.26 mi (1,038.44 km) |
| Des Moines to Destin (Florida) | 868.58 mi (1,397.84 km) |
| Des Moines to Destrehan (Louisiana) | 822.33 mi (1,323.42 km) |
| Des Moines to Detroit (Michigan) | 542.29 mi (872.73 km) |
| Des Moines to Diamond Bar (California) | 1,415.57 mi (2,278.13 km) |
| Des Moines to Diamond Springs (California) | 1,445.97 mi (2,327.06 km) |
| Des Moines to Dickinson (North Dakota) | 583.89 mi (939.68 km) |
| Des Moines to Dickinson (Texas) | 841.17 mi (1,353.73 km) |
| Des Moines to Dickson (Tennessee) | 507.50 mi (816.75 km) |
| Des Moines to Difficult Run (Virginia) | 876.01 mi (1,409.80 km) |
| Des Moines to Dinuba (California) | 1,420.66 mi (2,286.33 km) |
| Des Moines to Discovery Bay (California) | 1,501.64 mi (2,416.66 km) |
| Des Moines to Dix Hills (New York) | 1,053.04 mi (1,694.70 km) |
| Des Moines to Dixon (California) | 1,501.85 mi (2,417.00 km) |
