| Des Moines to Delaware (Ohio) | 556.80 mi (896.08 km) |
| Des Moines to Delhi (California) | 1,469.87 mi (2,365.53 km) |
| Des Moines to Delray Beach (Florida) | 1,296.70 mi (2,086.84 km) |
| Des Moines to Deltona (Florida) | 1,117.96 mi (1,799.18 km) |
| Des Moines to Deming (New Mexico) | 1,009.59 mi (1,624.77 km) |
| Des Moines to Denison (Texas) | 563.13 mi (906.26 km) |
| Des Moines to Dent (Ohio) | 498.68 mi (802.55 km) |
| Des Moines to Denton (Texas) | 608.80 mi (979.76 km) |
| Des Moines to Dentsville (South Carolina) | 861.84 mi (1,386.99 km) |
| Des Moines to Denver (Colorado) | 603.02 mi (970.47 km) |
| Des Moines to Depew (New York) | 767.03 mi (1,234.41 km) |
| Des Moines to Derby (Connecticut) | 1,060.69 mi (1,707.02 km) |
| Des Moines to Derby (Kansas) | 338.53 mi (544.82 km) |
| Des Moines to Des Moines (Washington) | 1,461.70 mi (2,352.38 km) |
| Des Moines to Des Plaines (Illinois) | 295.75 mi (475.96 km) |
