| Des Moines to Dallas (Oregon) | 1,504.03 mi (2,420.51 km) |
| Des Moines to Dallas (Texas) | 630.83 mi (1,015.23 km) |
| Des Moines to Dalton (Georgia) | 663.52 mi (1,067.83 km) |
| Des Moines to Daly City (California) | 1,551.48 mi (2,496.87 km) |
| Des Moines to Damascus (Maryland) | 876.55 mi (1,410.67 km) |
| Des Moines to Damascus (Oregon) | 1,461.23 mi (2,351.62 km) |
| Des Moines to Dana Point (California) | 1,427.45 mi (2,297.26 km) |
| Des Moines to Danbury (Connecticut) | 1,040.09 mi (1,673.86 km) |
| Des Moines to Dania Beach (Florida) | 1,317.31 mi (2,120.00 km) |
| Des Moines to Danville (California) | 1,522.89 mi (2,450.85 km) |
| Des Moines to Danville (Illinois) | 328.63 mi (528.88 km) |
| Des Moines to Danville (Indiana) | 392.93 mi (632.36 km) |
| Des Moines to Danville (Kentucky) | 542.58 mi (873.19 km) |
| Des Moines to Danville (Virginia) | 834.74 mi (1,343.39 km) |
| Des Moines to Daphne (Alabama) | 820.64 mi (1,320.70 km) |
