| Des Moines to Clarksdale (Mississippi) | 536.05 mi (862.68 km) |
| Des Moines to Clarkston (Georgia) | 740.71 mi (1,192.06 km) |
| Des Moines to Clarksville (Indiana) | 472.00 mi (759.61 km) |
| Des Moines to Clarksville (Tennessee) | 482.01 mi (775.73 km) |
| Des Moines to Clawson (Michigan) | 540.39 mi (869.68 km) |
| Des Moines to Clay (Alabama) | 665.05 mi (1,070.29 km) |
| Des Moines to Clayton (California) | 1,518.01 mi (2,443.00 km) |
| Des Moines to Clayton (Missouri) | 266.37 mi (428.68 km) |
| Des Moines to Clayton (North Carolina) | 913.00 mi (1,469.33 km) |
| Des Moines to Clayton (Ohio) | 499.80 mi (804.34 km) |
| Des Moines to Clearfield (Utah) | 953.97 mi (1,535.27 km) |
| Des Moines to Clearlake (California) | 1,533.45 mi (2,467.84 km) |
| Des Moines to Clearwater (Florida) | 1,120.91 mi (1,803.93 km) |
| Des Moines to Cleburne (Texas) | 670.29 mi (1,078.73 km) |
| Des Moines to Clemmons (North Carolina) | 807.19 mi (1,299.04 km) |
