| Des Moines to Central Point (Oregon) | 1,498.64 mi (2,411.82 km) |
| Des Moines to Centralia (Illinois) | 317.32 mi (510.67 km) |
| Des Moines to Centralia (Washington) | 1,489.00 mi (2,396.31 km) |
| Des Moines to Centreville (Virginia) | 872.60 mi (1,404.31 km) |
| Des Moines to Ceres (California) | 1,475.69 mi (2,374.89 km) |
| Des Moines to Cerritos (California) | 1,432.62 mi (2,305.59 km) |
| Des Moines to Chalco (Nebraska) | 133.65 mi (215.09 km) |
| Des Moines to Chalmette (Louisiana) | 828.82 mi (1,333.85 km) |
| Des Moines to Chambersburg (Pennsylvania) | 841.52 mi (1,354.30 km) |
| Des Moines to Chamblee (Georgia) | 734.65 mi (1,182.31 km) |
| Des Moines to Champaign (Illinois) | 296.53 mi (477.21 km) |
| Des Moines to Champlin (Minnesota) | 248.82 mi (400.44 km) |
| Des Moines to Chandler (Arizona) | 1,149.70 mi (1,850.27 km) |
| Des Moines to Chanhassen (Minnesota) | 226.78 mi (364.97 km) |
| Des Moines to Channahon (Illinois) | 277.05 mi (445.87 km) |
