| Des Moines to Anoka (Minnesota) | 251.56 mi (404.85 km) |
| Des Moines to Ansonia (Connecticut) | 1,061.27 mi (1,707.94 km) |
| Des Moines to Antelope (California) | 1,472.48 mi (2,369.73 km) |
| Des Moines to Anthem (Arizona) | 1,140.06 mi (1,834.75 km) |
| Des Moines to Antioch (California) | 1,510.24 mi (2,430.50 km) |
| Des Moines to Antioch (Illinois) | 290.96 mi (468.26 km) |
| Des Moines to Apache Junction (Arizona) | 1,130.16 mi (1,818.81 km) |
| Des Moines to Apex (North Carolina) | 890.32 mi (1,432.83 km) |
| Des Moines to Apollo Beach (Florida) | 1,145.06 mi (1,842.79 km) |
| Des Moines to Apopka (Florida) | 1,118.57 mi (1,800.16 km) |
| Des Moines to Apple Valley (California) | 1,367.58 mi (2,200.91 km) |
| Des Moines to Apple Valley (Minnesota) | 220.22 mi (354.41 km) |
| Des Moines to Appleton (Wisconsin) | 323.51 mi (520.63 km) |
| Des Moines to Arbutus (Maryland) | 903.00 mi (1,453.23 km) |
| Des Moines to Arcadia (California) | 1,422.22 mi (2,288.84 km) |
