| Depew to Yonkers (New York) | 283.23 mi (455.82 km) |
| Depew to Yorba Linda (California) | 2,183.65 mi (3,514.25 km) |
| Depew to York (Pennsylvania) | 227.78 mi (366.58 km) |
| Depew to Yorktown (Indiana) | 399.17 mi (642.41 km) |
| Depew to Yorkville (Illinois) | 505.40 mi (813.35 km) |
| Depew to Youngstown (Ohio) | 160.07 mi (257.60 km) |
| Depew to Youngsville (Louisiana) | 1,149.85 mi (1,850.51 km) |
| Depew to Ypsilanti (Michigan) | 254.32 mi (409.29 km) |
| Depew to Yuba City (California) | 2,228.76 mi (3,586.85 km) |
| Depew to Yucaipa (California) | 2,142.14 mi (3,447.44 km) |
| Depew to Yucca Valley (California) | 2,107.85 mi (3,392.25 km) |
| Depew to Yukon (Oklahoma) | 1,137.38 mi (1,830.43 km) |
| Depew to Yulee (Florida) | 862.77 mi (1,388.50 km) |
| Depew to Yuma (Arizona) | 2,065.17 mi (3,323.57 km) |
| Depew to Zachary (Louisiana) | 1,088.96 mi (1,752.52 km) |
