| Depew to University Place (Washington) | 2,131.55 mi (3,430.40 km) |
| Depew to Upland (California) | 2,170.60 mi (3,493.24 km) |
| Depew to Upper Arlington (Ohio) | 301.28 mi (484.87 km) |
| Depew to Upper Grand Lagoon (Florida) | 962.30 mi (1,548.67 km) |
| Depew to Upper Montclair (New Jersey) | 272.17 mi (438.01 km) |
| Depew to Urbana (Illinois) | 527.53 mi (848.98 km) |
| Depew to Urbana (Maryland) | 257.59 mi (414.56 km) |
| Depew to Urbana (Ohio) | 325.14 mi (523.26 km) |
| Depew to Urbandale (Iowa) | 774.73 mi (1,246.80 km) |
| Depew to Utica (New York) | 176.20 mi (283.56 km) |
| Depew to Uvalde (Texas) | 1,502.78 mi (2,418.49 km) |
| Depew to Vacaville (California) | 2,264.87 mi (3,644.96 km) |
| Depew to Vadnais Heights (Minnesota) | 728.60 mi (1,172.56 km) |
| Depew to Vail (Arizona) | 1,894.19 mi (3,048.40 km) |
| Depew to Valdosta (Georgia) | 870.51 mi (1,400.95 km) |
