| Depew to Superior (Colorado) | 1,380.11 mi (2,221.07 km) |
| Depew to Superior (Wisconsin) | 704.87 mi (1,134.37 km) |
| Depew to Surprise (Arizona) | 1,922.70 mi (3,094.29 km) |
| Depew to Susanville (California) | 2,147.55 mi (3,456.15 km) |
| Depew to Sussex (Wisconsin) | 480.78 mi (773.74 km) |
| Depew to Suwanee (Georgia) | 677.13 mi (1,089.73 km) |
| Depew to Swansea (Illinois) | 662.32 mi (1,065.89 km) |
| Depew to Sweetwater (Florida) | 1,187.56 mi (1,911.20 km) |
| Depew to Sweetwater (Texas) | 1,382.62 mi (2,225.11 km) |
| Depew to Sycamore (Illinois) | 512.27 mi (824.41 km) |
| Depew to Sylacauga (Alabama) | 787.47 mi (1,267.31 km) |
| Depew to Sylvania (Ohio) | 268.82 mi (432.62 km) |
| Depew to Syosset (New York) | 304.28 mi (489.68 km) |
| Depew to Syracuse (New York) | 129.74 mi (208.80 km) |
| Depew to Syracuse (Utah) | 1,706.62 mi (2,746.55 km) |
