| Depew to St. Simons (Georgia) | 824.01 mi (1,326.12 km) |
| Depew to Stafford (Texas) | 1,308.48 mi (2,105.79 km) |
| Depew to Stallings (North Carolina) | 549.22 mi (883.88 km) |
| Depew to Stamford (Connecticut) | 292.16 mi (470.18 km) |
| Depew to Stanford (California) | 2,299.82 mi (3,701.20 km) |
| Depew to Stanton (California) | 2,197.78 mi (3,536.99 km) |
| Depew to Star (Idaho) | 1,884.07 mi (3,032.12 km) |
| Depew to Starkville (Mississippi) | 852.36 mi (1,371.75 km) |
| Depew to State College (Pennsylvania) | 152.89 mi (246.06 km) |
| Depew to Staten Island (New York) | 284.55 mi (457.94 km) |
| Depew to Statesboro (Georgia) | 742.78 mi (1,195.39 km) |
| Depew to Statesville (North Carolina) | 505.85 mi (814.08 km) |
| Depew to Staunton (Virginia) | 328.90 mi (529.31 km) |
| Depew to Steamboat Springs (Colorado) | 1,453.64 mi (2,339.40 km) |
| Depew to Steiner Ranch (Texas) | 1,366.65 mi (2,199.41 km) |
