| Depew to Silver Firs (Washington) | 2,107.20 mi (3,391.21 km) |
| Depew to Silver Spring (Maryland) | 284.00 mi (457.05 km) |
| Depew to Silver Springs Shores (Florida) | 971.00 mi (1,562.67 km) |
| Depew to Silverdale (Washington) | 2,133.51 mi (3,433.55 km) |
| Depew to Silverton (Oregon) | 2,169.83 mi (3,492.01 km) |
| Depew to Simi Valley (California) | 2,220.85 mi (3,574.11 km) |
| Depew to Simpsonville (South Carolina) | 596.71 mi (960.31 km) |
| Depew to Sioux City (Iowa) | 896.79 mi (1,443.25 km) |
| Depew to Sioux Falls (South Dakota) | 906.83 mi (1,459.40 km) |
| Depew to Skokie (Illinois) | 464.21 mi (747.07 km) |
| Depew to Sleepy Hollow (New York) | 278.03 mi (447.45 km) |
| Depew to Slidell (Louisiana) | 1,064.81 mi (1,713.65 km) |
| Depew to Smithfield (North Carolina) | 511.54 mi (823.24 km) |
| Depew to Smithfield (Utah) | 1,681.38 mi (2,705.92 km) |
| Depew to Smithville (Missouri) | 859.22 mi (1,382.78 km) |
