| Depew to Santa Rosa (California) | 2,299.73 mi (3,701.07 km) |
| Depew to Santaquin (Utah) | 1,714.72 mi (2,759.57 km) |
| Depew to Santee (California) | 2,178.65 mi (3,506.20 km) |
| Depew to Sapulpa (Oklahoma) | 1,040.56 mi (1,674.62 km) |
| Depew to Saraland (Alabama) | 980.58 mi (1,578.10 km) |
| Depew to Sarasota (Florida) | 1,097.32 mi (1,765.96 km) |
| Depew to Sarasota Springs (Florida) | 1,098.61 mi (1,768.04 km) |
| Depew to Saratoga (California) | 2,297.02 mi (3,696.70 km) |
| Depew to Saratoga Springs (New York) | 249.20 mi (401.04 km) |
| Depew to Saratoga Springs (Utah) | 1,713.13 mi (2,757.02 km) |
| Depew to Sartell (Minnesota) | 788.80 mi (1,269.45 km) |
| Depew to Satellite Beach (Florida) | 1,023.49 mi (1,647.15 km) |
| Depew to Sauk Rapids (Minnesota) | 785.40 mi (1,263.98 km) |
| Depew to Sault Ste. Marie (Michigan) | 371.76 mi (598.29 km) |
| Depew to Savage (Minnesota) | 740.57 mi (1,191.82 km) |
