| Depew to Reidsville (North Carolina) | 457.14 mi (735.69 km) |
| Depew to Reisterstown (Maryland) | 258.26 mi (415.63 km) |
| Depew to Rendon (Texas) | 1,234.31 mi (1,986.44 km) |
| Depew to Reno (Nevada) | 2,129.14 mi (3,426.52 km) |
| Depew to Renton (Washington) | 2,112.57 mi (3,399.86 km) |
| Depew to Republic (Missouri) | 874.03 mi (1,406.62 km) |
| Depew to Reston (Virginia) | 282.77 mi (455.08 km) |
| Depew to Revere (Massachusetts) | 392.56 mi (631.77 km) |
| Depew to Rexburg (Idaho) | 1,652.02 mi (2,658.67 km) |
| Depew to Reynoldsburg (Ohio) | 294.06 mi (473.25 km) |
| Depew to Rialto (California) | 2,156.91 mi (3,471.20 km) |
| Depew to Richardson (Texas) | 1,193.47 mi (1,920.71 km) |
| Depew to Richfield (Minnesota) | 737.39 mi (1,186.72 km) |
| Depew to Richfield (Wisconsin) | 481.60 mi (775.06 km) |
| Depew to Richland (Washington) | 1,988.45 mi (3,200.11 km) |
