| Depew to Oswego (Illinois) | 499.27 mi (803.49 km) |
| Depew to Oswego (New York) | 117.12 mi (188.49 km) |
| Depew to Otsego (Minnesota) | 756.70 mi (1,217.79 km) |
| Depew to Ottawa (Illinois) | 529.30 mi (851.83 km) |
| Depew to Ottawa (Kansas) | 914.62 mi (1,471.94 km) |
| Depew to Ottumwa (Iowa) | 715.74 mi (1,151.87 km) |
| Depew to Overland (Missouri) | 675.20 mi (1,086.64 km) |
| Depew to Overland Park (Kansas) | 878.16 mi (1,413.27 km) |
| Depew to Overlea (Maryland) | 270.21 mi (434.87 km) |
| Depew to Oviedo (Florida) | 994.50 mi (1,600.49 km) |
| Depew to Owasso (Oklahoma) | 1,017.58 mi (1,637.63 km) |
| Depew to Owatonna (Minnesota) | 731.63 mi (1,177.44 km) |
| Depew to Owensboro (Kentucky) | 567.97 mi (914.06 km) |
| Depew to Owings Mills (Maryland) | 261.50 mi (420.84 km) |
| Depew to Owosso (Michigan) | 276.71 mi (445.33 km) |
