| Depew to Orangevale (California) | 2,218.97 mi (3,571.09 km) |
| Depew to Orchards (Washington) | 2,148.48 mi (3,457.64 km) |
| Depew to Orcutt (California) | 2,286.46 mi (3,679.69 km) |
| Depew to Oregon (Ohio) | 256.82 mi (413.31 km) |
| Depew to Oregon (Wisconsin) | 540.28 mi (869.49 km) |
| Depew to Oregon City (Oregon) | 2,156.07 mi (3,469.85 km) |
| Depew to Orem (Utah) | 1,703.20 mi (2,741.03 km) |
| Depew to Orinda (California) | 2,288.08 mi (3,682.31 km) |
| Depew to Orland Park (Illinois) | 476.62 mi (767.05 km) |
| Depew to Orlando (Florida) | 1,008.06 mi (1,622.32 km) |
| Depew to Ormond Beach (Florida) | 949.94 mi (1,528.79 km) |
| Depew to Oro Valley (Arizona) | 1,893.49 mi (3,047.28 km) |
| Depew to Oroville (California) | 2,216.19 mi (3,566.61 km) |
| Depew to Oshkosh (Wisconsin) | 499.93 mi (804.55 km) |
| Depew to Oskaloosa (Iowa) | 722.26 mi (1,162.37 km) |
