| Depew to Odessa (Texas) | 1,497.22 mi (2,409.54 km) |
| Depew to Ogden (Utah) | 1,698.94 mi (2,734.18 km) |
| Depew to Oildale (California) | 2,198.83 mi (3,538.67 km) |
| Depew to Ojus (Florida) | 1,174.40 mi (1,890.01 km) |
| Depew to Okemos (Michigan) | 289.69 mi (466.20 km) |
| Depew to Oklahoma City (Oklahoma) | 1,127.47 mi (1,814.49 km) |
| Depew to Okmulgee (Oklahoma) | 1,051.16 mi (1,691.68 km) |
| Depew to Olathe (Kansas) | 884.83 mi (1,423.99 km) |
| Depew to Old Jamestown (Missouri) | 666.46 mi (1,072.56 km) |
| Depew to Oldsmar (Florida) | 1,050.43 mi (1,690.50 km) |
| Depew to Olean (New York) | 58.99 mi (94.94 km) |
| Depew to Olive Branch (Mississippi) | 811.32 mi (1,305.70 km) |
| Depew to Olivehurst (California) | 2,226.05 mi (3,582.49 km) |
| Depew to Olney (Maryland) | 273.71 mi (440.49 km) |
| Depew to Olympia (Washington) | 2,149.60 mi (3,459.45 km) |
