| Depew to St. Louis (Missouri) | 671.46 mi (1,080.61 km) |
| Depew to Atlanta (Georgia) | 703.56 mi (1,132.27 km) |
| Depew to Minneapolis (Minnesota) | 737.26 mi (1,186.50 km) |
| Depew to Tampa (Florida) | 1,051.66 mi (1,692.49 km) |
| Depew to Miami (Florida) | 1,186.47 mi (1,909.44 km) |
| Depew to Dallas (Texas) | 1,204.00 mi (1,937.65 km) |
| Depew to Houston (Texas) | 1,293.23 mi (2,081.25 km) |
| Depew to Denver (Colorado) | 1,369.35 mi (2,203.76 km) |
| Depew to Phoenix (Arizona) | 1,908.27 mi (3,071.07 km) |
| Depew to Las Vegas (Nevada) | 1,984.48 mi (3,193.71 km) |
| Depew to Seattle (Washington) | 2,117.39 mi (3,407.61 km) |
| Depew to Portland (Oregon) | 2,156.15 mi (3,469.99 km) |
| Depew to Riverside (California) | 2,163.03 mi (3,481.06 km) |
| Depew to San Diego (California) | 2,186.38 mi (3,518.65 km) |
| Depew to Los Angeles (California) | 2,208.45 mi (3,554.15 km) |
| Depew to San Francisco (California) | 2,304.81 mi (3,709.23 km) |
| Depew to Detroit (Michigan) | 226.45 mi (364.43 km) |
| Depew to Baltimore (Maryland) | 271.89 mi (437.56 km) |
| Depew to Philadelphia (Pennsylvania) | 272.78 mi (439.00 km) |
| Depew to New York (New York) | 289.88 mi (466.51 km) |
| Depew to Brooklyn (New York) | 290.50 mi (467.52 km) |
| Depew to Washington (District of Columbia) | 290.54 mi (467.58 km) |
| Depew to Queens (New York) | 293.40 mi (472.18 km) |
| Depew to Boston (Massachusetts) | 389.43 mi (626.73 km) |
| Depew to Chicago (Illinois) | 464.22 mi (747.09 km) |
