| Defiance to Yonkers (New York) | 546.65 mi (879.75 km) |
| Defiance to Yorba Linda (California) | 1,886.14 mi (3,035.45 km) |
| Defiance to York (Pennsylvania) | 410.40 mi (660.48 km) |
| Defiance to Yorktown (Indiana) | 96.76 mi (155.72 km) |
| Defiance to Yorkville (Illinois) | 213.05 mi (342.87 km) |
| Defiance to Youngstown (Ohio) | 193.78 mi (311.86 km) |
| Defiance to Youngsville (Louisiana) | 882.63 mi (1,420.46 km) |
| Defiance to Ypsilanti (Michigan) | 76.80 mi (123.60 km) |
| Defiance to Yuba City (California) | 1,957.22 mi (3,149.85 km) |
| Defiance to Yucaipa (California) | 1,844.16 mi (2,967.88 km) |
| Defiance to Yucca Valley (California) | 1,809.37 mi (2,911.90 km) |
| Defiance to Yukon (Oklahoma) | 826.17 mi (1,329.60 km) |
| Defiance to Yulee (Florida) | 751.93 mi (1,210.11 km) |
| Defiance to Yuma (Arizona) | 1,760.75 mi (2,833.65 km) |
| Defiance to Zachary (Louisiana) | 825.51 mi (1,328.53 km) |
