| Defiance to Worthington (Ohio) | 108.08 mi (173.94 km) |
| Defiance to Wright (Florida) | 759.44 mi (1,222.20 km) |
| Defiance to Wyandanch (New York) | 574.38 mi (924.37 km) |
| Defiance to Wyandotte (Michigan) | 89.55 mi (144.11 km) |
| Defiance to Wylie (Texas) | 877.19 mi (1,411.70 km) |
| Defiance to Wyndham (Virginia) | 437.02 mi (703.31 km) |
| Defiance to Wyoming (Michigan) | 130.74 mi (210.41 km) |
| Defiance to Wyomissing (Pennsylvania) | 443.76 mi (714.16 km) |
| Defiance to Xenia (Ohio) | 112.67 mi (181.32 km) |
| Defiance to Yakima (Washington) | 1,820.55 mi (2,929.89 km) |
| Defiance to Yankton (South Dakota) | 676.46 mi (1,088.66 km) |
| Defiance to Yauco (Puerto Rico) | 1,911.06 mi (3,075.56 km) |
| Defiance to Yazoo City (Mississippi) | 669.90 mi (1,078.10 km) |
| Defiance to Yeadon (Pennsylvania) | 486.78 mi (783.39 km) |
| Defiance to Yelm (Washington) | 1,917.93 mi (3,086.61 km) |
