| Defiance to University Place (Washington) | 1,913.47 mi (3,079.43 km) |
| Defiance to Upland (California) | 1,873.62 mi (3,015.31 km) |
| Defiance to Upper Arlington (Ohio) | 110.08 mi (177.16 km) |
| Defiance to Upper Grand Lagoon (Florida) | 771.62 mi (1,241.80 km) |
| Defiance to Upper Montclair (New Jersey) | 530.12 mi (853.15 km) |
| Defiance to Urbana (Illinois) | 216.38 mi (348.22 km) |
| Defiance to Urbana (Maryland) | 393.79 mi (633.74 km) |
| Defiance to Urbana (Ohio) | 87.14 mi (140.23 km) |
| Defiance to Urbandale (Iowa) | 487.91 mi (785.22 km) |
| Defiance to Utica (New York) | 484.12 mi (779.12 km) |
| Defiance to Uvalde (Texas) | 1,201.17 mi (1,933.10 km) |
| Defiance to Vacaville (California) | 1,990.00 mi (3,202.60 km) |
| Defiance to Vadnais Heights (Minnesota) | 510.13 mi (820.98 km) |
| Defiance to Vail (Arizona) | 1,585.35 mi (2,551.38 km) |
| Defiance to Valdosta (Georgia) | 723.25 mi (1,163.96 km) |
