| Defiance to Superior (Colorado) | 1,092.03 mi (1,757.46 km) |
| Defiance to Superior (Wisconsin) | 535.26 mi (861.41 km) |
| Defiance to Surprise (Arizona) | 1,618.53 mi (2,604.77 km) |
| Defiance to Susanville (California) | 1,881.49 mi (3,027.96 km) |
| Defiance to Sussex (Wisconsin) | 235.25 mi (378.59 km) |
| Defiance to Suwanee (Georgia) | 499.84 mi (804.42 km) |
| Defiance to Swansea (Illinois) | 352.44 mi (567.20 km) |
| Defiance to Sweetwater (Florida) | 1,095.17 mi (1,762.50 km) |
| Defiance to Sweetwater (Texas) | 1,072.84 mi (1,726.56 km) |
| Defiance to Sycamore (Illinois) | 228.26 mi (367.35 km) |
| Defiance to Sylacauga (Alabama) | 569.46 mi (916.46 km) |
| Defiance to Sylvania (Ohio) | 45.07 mi (72.54 km) |
| Defiance to Syosset (New York) | 566.62 mi (911.88 km) |
| Defiance to Syracuse (New York) | 438.08 mi (705.03 km) |
| Defiance to Syracuse (Utah) | 1,434.51 mi (2,308.62 km) |
