| Defiance to Storm Lake (Iowa) | 563.92 mi (907.53 km) |
| Defiance to Storrs (Connecticut) | 626.99 mi (1,009.04 km) |
| Defiance to Stoughton (Wisconsin) | 273.56 mi (440.25 km) |
| Defiance to Stow (Ohio) | 152.49 mi (245.40 km) |
| Defiance to Streamwood (Illinois) | 203.32 mi (327.21 km) |
| Defiance to Streator (Illinois) | 232.29 mi (373.83 km) |
| Defiance to Streetsboro (Ohio) | 156.88 mi (252.47 km) |
| Defiance to Strongsville (Ohio) | 131.57 mi (211.75 km) |
| Defiance to Stuart (Florida) | 1,000.94 mi (1,610.85 km) |
| Defiance to Stuarts Draft (Virginia) | 362.12 mi (582.78 km) |
| Defiance to Sturgis (Michigan) | 65.14 mi (104.84 km) |
| Defiance to Suamico (Wisconsin) | 297.86 mi (479.35 km) |
| Defiance to Sudley (Virginia) | 402.02 mi (646.99 km) |
| Defiance to Suffern (New York) | 531.33 mi (855.09 km) |
| Defiance to Suffolk (Virginia) | 521.71 mi (839.61 km) |
