| Defiance to Stephenville (Texas) | 988.16 mi (1,590.29 km) |
| Defiance to Sterling (Colorado) | 981.60 mi (1,579.73 km) |
| Defiance to Sterling (Illinois) | 277.91 mi (447.25 km) |
| Defiance to Sterling (Virginia) | 399.71 mi (643.28 km) |
| Defiance to Sterling Heights (Michigan) | 113.02 mi (181.88 km) |
| Defiance to Steubenville (Ohio) | 204.21 mi (328.64 km) |
| Defiance to Stevens Point (Wisconsin) | 344.93 mi (555.11 km) |
| Defiance to Stevenson Ranch (California) | 1,913.80 mi (3,079.96 km) |
| Defiance to Stillwater (Minnesota) | 499.66 mi (804.12 km) |
| Defiance to Stillwater (Oklahoma) | 770.99 mi (1,240.79 km) |
| Defiance to Stockbridge (Georgia) | 535.93 mi (862.50 km) |
| Defiance to Stockton (California) | 1,964.34 mi (3,161.31 km) |
| Defiance to Stone Ridge (Virginia) | 394.72 mi (635.24 km) |
| Defiance to Stonecrest (Georgia) | 525.06 mi (845.00 km) |
| Defiance to Stony Brook (New York) | 585.34 mi (942.01 km) |
