| Defiance to St. Simons (Georgia) | 717.46 mi (1,154.64 km) |
| Defiance to Stafford (Texas) | 1,020.70 mi (1,642.66 km) |
| Defiance to Stallings (North Carolina) | 471.45 mi (758.72 km) |
| Defiance to Stamford (Connecticut) | 561.67 mi (903.92 km) |
| Defiance to Stanford (California) | 2,021.01 mi (3,252.49 km) |
| Defiance to Stanton (California) | 1,900.28 mi (3,058.21 km) |
| Defiance to Star (Idaho) | 1,634.94 mi (2,631.18 km) |
| Defiance to Starkville (Mississippi) | 593.12 mi (954.53 km) |
| Defiance to State College (Pennsylvania) | 340.83 mi (548.52 km) |
| Defiance to Staten Island (New York) | 535.13 mi (861.21 km) |
| Defiance to Statesboro (Georgia) | 627.52 mi (1,009.89 km) |
| Defiance to Statesville (North Carolina) | 424.08 mi (682.49 km) |
| Defiance to Staunton (Virginia) | 354.85 mi (571.08 km) |
| Defiance to Steamboat Springs (Colorado) | 1,171.29 mi (1,885.01 km) |
| Defiance to Steiner Ranch (Texas) | 1,066.78 mi (1,716.82 km) |
