| Defiance to St. George (Utah) | 1,583.43 mi (2,548.28 km) |
| Defiance to St. Helens (Oregon) | 1,931.50 mi (3,108.44 km) |
| Defiance to St. James (New York) | 584.30 mi (940.34 km) |
| Defiance to St. John (Indiana) | 161.34 mi (259.66 km) |
| Defiance to St. Joseph (Missouri) | 558.75 mi (899.22 km) |
| Defiance to St. Louis (Missouri) | 360.94 mi (580.87 km) |
| Defiance to St. Louis Park (Minnesota) | 519.40 mi (835.89 km) |
| Defiance to St. Marys (Georgia) | 743.63 mi (1,196.75 km) |
| Defiance to St. Marys (Pennsylvania) | 302.56 mi (486.93 km) |
| Defiance to St. Matthews (Kentucky) | 220.09 mi (354.20 km) |
| Defiance to St. Michael (Minnesota) | 541.45 mi (871.38 km) |
| Defiance to St. Paul (Minnesota) | 507.94 mi (817.45 km) |
| Defiance to St. Peter (Minnesota) | 529.83 mi (852.68 km) |
| Defiance to St. Peters (Missouri) | 372.43 mi (599.37 km) |
| Defiance to St. Petersburg (Florida) | 936.90 mi (1,507.80 km) |
